Résumés are confetti paper: Every graduate uses the same MS Word and WordPerfect templates, so all resumes look the same. When a company asks for a scannable (keyword) resume, candidates become even more indistinguishable!
Job skills change every few years. The average undergraduate student takes 5 years to get a B.S. degree. In that period of time, the entire world has changed.
Human Resource departments are there to keep you out, not grant you an interview. They are not the hiring decision makers, you future boss is.
Did you know that most jobs are never advertised? The jobs are filled before there is any need for an advertisement.